An Acid-Sensing Channel Sows Fear and Panic
نویسنده
چکیده
The amygdala is a brain region that coordinates fear responses to a variety of threats. Ziemann et al. (2009) now show that acid-sensing channels in the amygdala mediate fear responses that accompany inhalation of carbon dioxide, suggesting that aberrant chemosensation may underlie anxiety disorders associated with a fear of suffocation.
منابع مشابه
The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
The amygdala processes and directs inputs and outputs that are key to fear behavior. However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala expresses acid-sensing ion channel-1a (ASIC1a), and ASIC1a is required for normal fear responses, we hypothesized that the amygdala might detect a reduced pH. We found that inhaled CO(2) reduced brain pH and evoked fear be...
متن کاملThe human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function.
BACKGROUND Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene...
متن کاملASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory
Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and activity-induced long-term potentiation (LTP) of cortico-basolateral amygdala (BLA) synapses are impaired in ASIC1a-null mice, suggesting a critical role of ASICs in fear memory formation. In this study, we found that ASI...
متن کاملThe bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis.
Carbon dioxide (CO2) inhalation lowers brain pH and induces anxiety, fear, and panic responses in humans. In mice, CO2 produces freezing and avoidance behavior that has been suggested to depend on the amygdala. However, a recent study in humans with bilateral amygdala lesions revealed that CO2 can trigger fear and panic even in the absence of amygdalae, suggesting the importance of extra-amygda...
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Panic attacks are discrete episodes of intense fear or discomfort accompanied by symptoms such as palpitations, shortness of breath, sweating, trembling, derealization and a fear of losing control or dying. Although panic attacks are required for a diagnosis of panic disorder, they also occur in association with a host of other disorders listed in the 5h version of the diagnostic and statistica...
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عنوان ژورنال:
- Cell
دوره 139 شماره
صفحات -
تاریخ انتشار 2009